Literaturverzeichnis


Kapitel 1: Ja, der Reizdarm ist wirklich heilbar!

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2 Wahnschaffe U, Schulzke JD, Zeitz M, Ullrich R. Predictors of clinical response to gluten-free diet in patients diagnosed with diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol. 2007 Jul;5(7):844-50; quiz 769. doi: 10.1016/j.cgh.2007.03.021. Epub 2007 Jun 5. PMID: 17553753.

3 Koumbi L, Giouleme O, Vassilopoulou E. Non-Celiac Gluten Sensitivity and Irritable Bowel Disease: Looking for the Culprits. Curr Dev Nutr. 2020 Dec 31;4(12):nzaa176. doi: 10.1093/cdn/nzaa176. PMID: 33442571; PMCID: PMC7788486.

4 Vazquez-Roque MI, Camilleri M, Smyrk T, Murray JA, Marietta E, O'Neill J, Carlson P, Lamsam J, Janzow D, Eckert D, Burton D, Zinsmeister AR. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function. Gastroenterology. 2013 May;144(5):903-911.e3. doi: 10.1053/j.gastro.2013.01.049. Epub 2013 Jan 25. PMID: 23357715; PMCID: PMC3633663.

5 Losurdo G, Principi M, Iannone A, Amoruso A, Ierardi E, Di Leo A, Barone M. Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm. World J Gastroenterol. 2018 Apr 14;24(14):1521-1530. doi: 10.3748/wjg.v24.i14.1521. PMID: 29662290; PMCID: PMC5897856.

6 Nilholm C, Roth B, Ohlsson B. A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients. Nutrients. 2019 Jul 20;11(7):1662. doi: 10.3390/nu11071662. PMID: 31330810; PMCID: PMC6682926.

7 Peterson ML, Herber R. Intestinal sucrase deficiency. Trans Assoc Am Physicians. 1967;80:275-83. PMID: 6082247.

8 Garcia-Etxebarria K, Zheng T, Bonfiglio F, Bujanda L, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Jonkers D, Eswaran S, Chey WD, Kashyap P, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, D'Amato M. Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1673-1676. doi: 10.1016/j.cgh.2018.01.047. Epub 2018 Feb 21. PMID: 29408290; PMCID: PMC6103908.

9 Takakura W, Pimentel M. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome – An Update. Front Psychiatry. 2020 Jul 10;11:664. doi: 10.3389/fpsyt.2020.00664. PMID: 32754068; PMCID: PMC7366247.

10 Pimentel M, Chow EJ, Lin HC. Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome. Am J Gastroenterol. 2000 Dec;95(12):3503-6. doi: 10.1111/j.1572-0241.2000.03368.x. PMID: 11151884.

11 Ghoshal UC, Shukla R, Ghoshal U. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy. Gut Liver. 2017 Mar 15;11(2):196-208. doi: 10.5009/gnl16126. PMID: 28274108; PMCID: PMC5347643.

 

12 Ghoshal UC, Srivastava D, Misra A, Ghoshal U. A proof-of-concept study showing antibiotics to be more effective in irritable bowel syndrome with than without small-intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial. Eur J Gastroenterol Hepatol. 2016 Mar;28(3):281-9. doi: 10.1097/MEG.0000000000000557. PMID: 26731696.

 

Kapitel 2: Das weiß die Wissenschaft heute

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9 Kim YS, Kim N. Sex-Gender Differences in Irritable Bowel Syndrome. J Neurogastroenterol Motil. 2018 Oct 1;24(4):544-558. doi: 10.5056/jnm18082. PMID: 30347934; PMCID: PMC6175559.

10 Pretorius L, Van Staden ADP, Van der Merwe JJ, Henning N, Smith C. Alterations to microbial secretome by estrogen may contribute to sex bias in irritable bowel syndrome. Inflammopharmacology. 2022 Feb;30(1):267-281. doi: 10.1007/s10787-021-00906-8. Epub 2022 Jan 13. PMID: 35022916.

11 Toner BB. Cognitive-behavioral treatment of irritable bowel syndrome. CNS Spectr. 2005 Nov;10(11):883-90. doi: 10.1017/s1092852900019854. PMID: 16273018.

12 Creed F. Review article: the incidence and risk factors for irritable bowel syndrome in population-based studies. Aliment Pharmacol Ther. 2019 Sep;50(5):507-516. doi: 10.1111/apt.15396. Epub 2019 Jul 17. PMID: 31313850.

13 Mönnikes H. Quality of life in patients with irritable bowel syndrome. J Clin Gastroenterol. 2011 Aug;45 Suppl:S98-101. doi: 10.1097/MCG.0b013e31821fbf44. PMID: 21666428.

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72 Spiegel BM. The burden of IBS: looking at metrics. Curr Gastroenterol Rep. 2009 Aug;11(4):265-9. doi: 10.1007/s11894-009-0039-x. PMID: 19615301.

73 Chey WD, Nojkov B, Rubenstein JH, Dobhan RR, Greenson JK, Cash BD. The yield of colonoscopy in patients with non-constipated irritable bowel syndrome: results from a prospective, controlled US trial. Am J Gastroenterol. 2010 Apr;105(4):859-65. doi: 10.1038/ajg.2010.55. Epub 2010 Feb 23. PMID: 20179696; PMCID: PMC2887227.

74 Suleiman S, Sonnenberg A. Cost-effectiveness of endoscopy in irritable bowel syndrome. Arch Intern Med. 2001 Feb 12;161(3):369-75. doi: 10.1001/archinte.161.3.369. PMID: 11176762.

75 Hovdenak N. Loperamide treatment of the irritable bowel syndrome. Scand J Gastroenterol Suppl. 1987;130:81-4. doi: 10.3109/00365528709091004. PMID: 3306904.

76 Hanauer SB. The role of loperamide in gastrointestinal disorders. Rev Gastroenterol Disord. 2008 Winter;8(1):15-20. PMID: 18477966.

77 Palmer KR, Corbett CL, Holdsworth CD. Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea. Gastroenterology. 1980 Dec;79(6):1272-5. PMID: 7002706.

78 Lee AA, Baker JR, Wamsteker EJ, Saad R, DiMagno MJ. Small Intestinal Bacterial Overgrowth Is Common in Chronic Pancreatitis and Associates With Diabetes, Chronic Pancreatitis Severity, Low Zinc Levels, and Opiate Use. Am J Gastroenterol. 2019 Jul;114(7):1163-1171. doi: 10.14309/ajg.0000000000000200. PMID: 31008737; PMCID: PMC6610753.

79 Blunk JA, Schmelz M, Zeck S, Skov P, Likar R, Koppert W. Opioid-induced mast cell activation and vascular responses is not mediated by mu-opioid receptors: an in vivo microdialysis study in human skin. Anesth Analg. 2004 Feb;98(2):364-70, table of contents. doi: 10.1213/01.ane.0000097168.32472.0d. PMID: 14742371.

80 Usai-Satta P, Bellini M, Lai M, Oppia F, Cabras F. Therapeutic Approach for Irritable Bowel Syndrome: Old and New Strategies. Curr Clin Pharmacol. 2018;13(3):164-172. doi: 10.2174/1574884713666180807143606. PMID: 30084333.

81 Li J, Zhu W, Liu W, Wu Y, Wu B. Rifaximin for Irritable Bowel Syndrome: A Metaanalysis of Randomized Placebo-Controlled Trials. Medicine (Baltimore). 2016 Jan;95(4):e2534. doi: 10.1097/MD.0000000000002534. PMID: 26825893; PMCID: PMC5291563.

82 Qi Q, Zhang Y, Chen F, Zuo X, Li Y. Ramosetron for the treatment of irritable bowel syndrome with diarrhea: a systematic review and meta-analysis of randomized controlled trials. BMC Gastroenterol. 2018 Jan 8;18(1):5. doi: 10.1186/s12876-017-0734-2. PMID: 29310568; PMCID: PMC5759234.

83 Ianiro G, Eusebi LH, Black CJ, Gasbarrini A, Cammarota G, Ford AC. Systematic review with meta-analysis: efficacy of faecal microbiota transplantation for the treatment of irritable bowel syndrome. Aliment Pharmacol Ther. 2019 Aug;50(3):240-248. doi: 10.1111/apt.15330. Epub 2019 May 28. PMID: 31136009.

84 Rahimi R, Nikfar S, Abdollahi M. Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin Ther. 2008 May;30(5):884-901. doi: 10.1016/j.clinthera.2008.05.002. PMID: 18555935.

85 Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019 Mar 5;26(10):2704-2719.e6. doi: 10.1016/j.celrep.2019.02.019. PMID: 30840892; PMCID: PMC6528490.

86 Chedid V, Dhalla S, Clarke JO, Roland BC, Dunbar KB, Koh J, Justino E, Tomakin E, Mullin GE. Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth. Glob Adv Health Med. 2014 May;3(3):16-24. doi: 10.7453/gahmj.2014.019. PMID: 24891990; PMCID: PMC4030608.

87 Pimentel M, Constantino T, Kong Y, Bajwa M, Rezaei A, Park S. A 14-day elemental diet is highly effective in normalizing the lactulose breath test. Dig Dis Sci. 2004 Jan;49(1):73-7. doi: 10.1023/b:ddas.0000011605.43979.e1. PMID: 14992438.

88 Berstad A, Hauso O, Berstad K, Berstad JER. From IBS to ME – The dysbiotic march hypothesis. Med Hypotheses. 2020 Feb 26;140:109648. doi: 10.1016/j.mehy.2020.109648. Epub ahead of print. PMID: 32126475.

89 Struppe T. Symptom-severity, comorbidities and quality of life of patients with Irritable Bowel Syndrome: Insights from a German-speaking online-cohort. 2020. Material gathered from an unpublished draft by Thomas Struppe, Zittau.

 

90 Maes M, Leunis JC. Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria. Neuro Endocrinol Lett. 2008 Dec;29(6):902-10. PMID: 19112401.

 

Kapitel 3: Abkürzungen zu einem besseren Bauchgefühl

1 Charoenngam N, Holick MF. Immunologic Effects of Vitamin D on Human Health and Disease. Nutrients. 2020 Jul 15;12(7):2097. doi: 10.3390/nu12072097. PMID: 32679784; PMCID: PMC7400911.

2 Zittermann A. The estimated benefits of vitamin D for Germany. Mol Nutr Food Res. 2010 Aug;54(8):1164-71. doi: 10.1002/mnfr.200900494. PMID: 20373291.

3 Grant WB, Schuitemaker GE. Health benefits of higher serum 25-hydroxyvitamin D levels in The Netherlands. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):456-8. doi: 10.1016/j.jsbmb.2010.03.089. Epub 2010 Apr 14. PMID: 20398763.

4 Khayyat Y, Attar S. Vitamin D Deficiency in Patients with Irritable Bowel Syndrome: Does it Exist? Oman Med J. 2015 Mar;30(2):115-8. doi: 10.5001/omj.2015.25. PMID: 25960837; PMCID: PMC4412886.

5 Bikle DD. Vitamin D insufficiency/deficiency in gastrointestinal disorders. J Bone Miner Res. 2007 Dec;22 Suppl 2:V50-4. doi: 10.1359/jbmr.07s208. PMID: 18290722.

6 Gominak SC. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity. Med Hypotheses. 2016 Sep;94:103-7. doi: 10.1016/j.mehy.2016.07.007. Epub 2016 Jul 14. PMID: 27515213.

7 Tabatabaeizadeh SA, Tafazoli N, Ferns GA, Avan A, Ghayour-Mobarhan M. Vitamin D, the gut microbiome and inflammatory bowel disease. J Res Med Sci. 2018 Aug 23;23:75. doi: 10.4103/jrms.JRMS_606_17. PMID: 30181757; PMCID: PMC6116667.

8 Gubatan J, Moss AC. Vitamin D in inflammatory bowel disease: more than just a supplement. Curr Opin Gastroenterol. 2018 Jul;34(4):217-225. doi: 10.1097/MOG.0000000000000449. PMID: 29762159.

9 Jalili M, Vahedi H, Poustchi H, Hekmatdoost A. Effects of Vitamin D Supplementation in Patients with Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Int J Prev Med. 2019 Feb 12;10:16. doi: 10.4103/ijpvm.IJPVM_512_17. PMID: 30820303; PMCID: PMC6390425.

10 Dukowicz AC, Lacy BE, Levine GM. Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol Hepatol (N Y). 2007 Feb;3(2):112-22. PMID: 21960820; PMCID: PMC3099351.

11 Compare D, Pica L, Rocco A, De Giorgi F, Cuomo R, Sarnelli G, Romano M, Nardone G. Effects of long-term PPI treatment on producing bowel symptoms and SIBO. Eur J Clin Invest. 2011 Apr;41(4):380-6. doi: 10.1111/j.1365-2362.2010.02419.x. Epub 2010 Dec 3. PMID: 21128930.

12 Sarna SK. Lessons Learnt from Post-Infectious IBS. Front Physiol. 2011 Aug 23;2:49. doi: 10.3389/fphys.2011.00049. PMID: 21897820; PMCID: PMC3159897.

13 Wang SH, Dong L, Luo JY, Li L, Zhu YL, Wang XQ, Zou BC, Gong J. A research of migrating motor complex in patients with irritable bowel syndrome. Zhonghua Nei Ke Za Zhi. 2009 Feb;48(2):106-10. Chinese. PMID: 19549462.

14 Avelar Rodriguez D, Ryan PM, Toro Monjaraz EM, Ramirez Mayans JA, Quigley EM. Small Intestinal Bacterial Overgrowth in Children: A State-Of-The-Art Review. Front Pediatr. 2019 Sep 4;7:363. doi: 10.3389/fped.2019.00363. PMID: 31552207; PMCID: PMC6737284.

15 Rao SSC, Rehman A, Yu S, Andino NM. Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. Clin Transl Gastroenterol. 2018 Jun 19;9(6):162. doi: 10.1038/s41424-018-0030-7. PMID: 29915215; PMCID: PMC6006167.

16 Ghoshal UC, Shukla R, Ghoshal U. Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy. Gut Liver. 2017 Mar 15;11(2):196-208. doi: 10.5009/gnl16126. PMID: 28274108; PMCID: PMC5347643.

17 Ghoshal UC, Srivastava D, Misra A, Ghoshal U. A proof-of-concept study showing antibiotics to be more effective in irritable bowel syndrome with than without small-intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial. Eur J Gastroenterol Hepatol. 2016 Mar;28(3):281-9. doi: 10.1097/MEG.0000000000000557. PMID: 26731696.

18 Losurdo G, Leandro G, Ierardi E, Perri F, Barone M, Principi M, Leo AD. Breath Tests for the Non-invasive Diagnosis of Small Intestinal Bacterial Overgrowth: A Systematic Review With Meta-analysis. J Neurogastroenterol Motil. 2020 Jan 30;26(1):16-28. doi: 10.5056/jnm19113. PMID: 31743632; PMCID: PMC6955189.

19 Nickles MA, Hasan A, Shakhbazova A, Wright S, Chambers CJ, Sivamani RK. Alternative Treatment Approaches to Small Intestinal Bacterial Overgrowth: A Systematic Review. J Altern Complement Med. 2021 Feb;27(2):108-119. doi: 10.1089/acm.2020.0275. Epub 2020 Oct 19. PMID: 33074705.

20 Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017 May 12;18(5):1051. doi: 10.3390/ijms18051051. PMID: 28498331; PMCID: PMC5454963.

21 Piche T. Tight junctions and IBS--the link between epithelial permeability, low-grade inflammation, and symptom generation? Neurogastroenterol Motil. 2014 Mar;26(3):296-302. doi: 10.1111/nmo.12315. PMID: 24548256.

22 Morris G, Berk M, Carvalho AF, Caso JR, Sanz Y, Maes M. The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome. Curr Pharm Des. 2016;22(40):6058-6075. doi: 10.2174/1381612822666160914182822. PMID: 27634186.

23 Long Y, Du L, Kim JJ, Chen B, Zhu Y, Zhang Y, Yao S, He H, Zheng X, Huang Z, Dai N. MLCK-mediated intestinal permeability promotes immune activation and visceral hypersensitivity in PI-IBS mice. Neurogastroenterol Motil. 2018 Sep;30(9):e13348. doi: 10.1111/nmo.13348. Epub 2018 Apr 11. PMID: 29644768.

24 Sadeghi A, Biglari M, Nasseri Moghaddam S. Post-infectious Irritable Bowel Syndrome: A Narrative Review. Middle East J Dig Dis. 2019 Apr;11(2):69-75. doi: 10.15171/mejdd.2019.130. Epub 2019 Mar 25. PMID: 31380002; PMCID: PMC6663289.

25 Barbara G, Stanghellini V, Cremon C, De Giorgio R, Corinaldesi R. Almost all irritable bowel syndromes are post-infectious and respond to probiotics: controversial issues. Dig Dis. 2007;25(3):245-8. doi: 10.1159/000103894. PMID: 17827949.

26 Rao R, Samak G. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. J Epithel Biol Pharmacol. 2012 Jan;5(Suppl 1-M7):47-54. doi: 10.2174/1875044301205010047. PMID: 25810794; PMCID: PMC4369670.

27 Nozu T, Miyagishi S, Ishioh M, Takakusaki K, Okumura T. Phlorizin attenuates visceral hypersensitivity and colonic hyperpermeability in a rat model of irritable bowel syndrome. Biomed Pharmacother. 2021 Jul;139:111649. doi: 10.1016/j.biopha.2021.111649. Epub 2021 May 3. PMID: 33957565.

28 Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN. Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome. Gut. 2019 Jun;68(6):996-1002. doi: 10.1136/gutjnl-2017-315136. Epub 2018 Aug 14. PMID: 30108163.

 

29 Fasano A. All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases. F1000Res. 2020 Jan 31;9:F1000 Faculty Rev-69. doi: 10.12688/f1000research.20510.1. PMID: 32051759; PMCID: PMC6996528.

 

Kapitel 4: Die mediterrane Low-FODMAP-Diät: Grundlage für die Genesung

1 Corsello A, Pugliese D, Gasbarrini A, Armuzzi A. Diet and Nutrients in Gastrointestinal Chronic Diseases. Nutrients. 2020 Sep 3;12(9):2693. doi: 10.3390/nu12092693. PMID: 32899273; PMCID: PMC7551310.

2 Buscail C, Sabate JM, Bouchoucha M, Kesse-Guyot E, Hercberg S, Benamouzig R, Julia C. Western Dietary Pattern Is Associated with Irritable Bowel Syndrome in the French NutriNet Cohort. Nutrients. 2017 Sep 7;9(9):986. doi: 10.3390/nu9090986. PMID: 28880222; PMCID: PMC5622746.

3 Hills RD Jr, Pontefract BA, Mishcon HR, Black CA, Sutton SC, Theberge CR. Gut Microbiome: Profound Implications for Diet and Disease. Nutrients. 2019 Jul 16;11(7):1613. doi: 10.3390/nu11071613. PMID: 31315227; PMCID: PMC6682904.

4 Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, Wong K, Abrouk M, Farahnik B, Nakamura M, Zhu TH, Bhutani T, Liao W. Influence of diet on the gut microbiome and implications for human health. J Transl Med. 2017 Apr 8;15(1):73. doi: 10.1186/s12967-017-1175-y. PMID: 28388917; PMCID: PMC5385025.

5 Werlang ME, Palmer WC, Lacy BE. Irritable Bowel Syndrome and Dietary Interventions. Gastroenterol Hepatol (N Y). 2019 Jan;15(1):16-26. PMID: 30899204; PMCID: PMC6423692.

6 Altobelli E, Del Negro V, Angeletti PM, Latella G. Low-FODMAP Diet Improves Irritable Bowel Syndrome Symptoms: A Metaanalysis. Nutrients. 2017 Aug 26;9(9):940. doi: 10.3390/nu9090940. PMID: 28846594; PMCID: PMC5622700.

7 Yang J, Fox M, Cong Y, Chu H, Zheng X, Long Y, Fried M, Dai N. Lactose intolerance in irritable bowel syndrome patients with diarrhoea: the roles of anxiety, activation of the innate mucosal immune system and visceral sensitivity. Aliment Pharmacol Ther. 2014 Feb;39(3):302-11. doi: 10.1111/apt.12582. Epub 2013 Dec 5. PMID: 24308871.

8 Misselwitz B, Pohl D, Frühauf H, Fried M, Vavricka SR, Fox M. Lactose malabsorption and intolerance: pathogenesis, diagnosis and treatment. United European Gastroenterol J. 2013 Jun;1(3):151-9. doi: 10.1177/2050640613484463. PMID: 24917953; PMCID: PMC4040760.

9 Staudacher HM, Whelan K. The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS. Gut. 2017 Aug;66(8):1517-1527. doi: 10.1136/gutjnl-2017-313750. Epub 2017 Jun 7. PMID: 28592442.

10 Suarez FL, Springfield J, Levitt MD. Identification of gases responsible for the odour of human flatus and evaluation of a device purported to reduce this odour. Gut. 1998 Jul;43(1):100-4. doi: 10.1136/gut.43.1.100. PMID: 9771412; PMCID: PMC1727181.

11 Murray K, Wilkinson-Smith V, Hoad C, Costigan C, Cox E, Lam C, Marciani L, Gowland P, Spiller RC. Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI. Am J Gastroenterol. 2014 Jan;109(1):110-9. doi: 10.1038/ajg.2013.386. Epub 2013 Nov 19. PMID: 24247211; PMCID: PMC3887576.

12 van Lanen AS, de Bree A, Greyling A. Efficacy of a Low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis. Eur J Nutr. 2021 Feb 14. doi: 10.1007/s00394-020-02473-0. Epub ahead of print. Erratum in: Eur J Nutr. 2021 Jun 28;: PMID: 33585949.

13 Eswaran SL, Chey WD, Han-Markey T, Ball S, Jackson K. A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D. Am J Gastroenterol. 2016 Dec;111(12):1824-1832. doi: 10.1038/ajg.2016.434. Epub 2016 Oct 11. PMID: 27725652.

14 Zhou SY, Gillilland M 3rd, Wu X, Leelasinjaroen P, Zhang G, Zhou H, Ye B, Lu Y, Owyang C. FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction. J Clin Invest. 2018 Jan 2;128(1):267-280. doi: 10.1172/JCI92390. Epub 2017 Nov 27. PMID: 29202473; PMCID: PMC5749529.

15 McIntosh K, Reed DE, Schneider T, Dang F, Keshteli AH, De Palma G, Madsen K, Bercik P, Vanner S. FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial. Gut. 2017 Jul;66(7):1241-1251. doi: 10.1136/gutjnl-2015-311339. Epub 2016 Mar 14. Erratum in: Gut. 2019 Jul;68(7):1342. PMID: 26976734.

16 Varney J, Barrett J, Scarlata K, Catsos P, Gibson PR, Muir JG. FODMAPs: food composition, defining cutoff values and international application. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:53-61. doi: 10.1111/jgh.13698. PMID: 28244665.

17 Paglia L. The sweet danger of added sugars. Eur J Paediatr Dent. 2019 Jun;20(2):89. doi: 10.23804/ejpd.2019.20.02.01. PMID: 31246081.

18 Zinöcker MK, Lindseth IA. The Western Diet-Microbiome-Host Interaction and Its Role in Metabolic Disease. Nutrients. 2018 Mar 17;10(3):365. doi: 10.3390/nu10030365. PMID: 29562591; PMCID: PMC5872783.

19 Bascuñán KA, Elli L, Pellegrini N, Scricciolo A, Lombardo V, Doneda L, Vecchi M, Scarpa C, Araya M, Roncoroni L. Impact of FODMAP Content Restrictions on the Quality of Diet for Patients with Celiac Disease on a Gluten-Free Diet. Nutrients. 2019 Sep 14;11(9):2220. doi: 10.3390/nu11092220. PMID: 31540014; PMCID: PMC6770200.

20 Staudacher HM, Ralph FSE, Irving PM, Whelan K, Lomer MCE. Nutrient Intake, Diet Quality, and Diet Diversity in Irritable Bowel Syndrome and the Impact of the Low FODMAP Diet. J Acad Nutr Diet. 2020 Apr;120(4):535-547. doi: 10.1016/j.jand.2019.01.017. Epub 2019 Apr 24. Erratum in: J Acad Nutr Diet. 2020 Dec;120(12):2098. PMID: 31029650.

21 Staudacher HM. Nutritional, microbiological and psychosocial implications of the low FODMAP diet. J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:16-19. doi: 10.1111/jgh.13688. PMID: 28244658.

22 Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM, Whelan K. Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial. Gastroenterology. 2020 Jan;158(1):176-188.e7. doi: 10.1053/j.gastro.2019.09.024. Epub 2019 Oct 2. PMID: 31586453.

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32 Koochakpoor G, Salari-Moghaddam A, Keshteli AH, Esmaillzadeh A, Adibi P. Association of Coffee and Caffeine Intake With Irritable Bowel Syndrome in Adults. Front Nutr. 2021 Jun 15;8:632469. doi: 10.3389/fnut.2021.632469. PMID: 34211993; PMCID: PMC8241212.

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36 Ernst, J.B., Arens-Azevêdo, U., Bitzer, B., Bosy-Westphal, A., Zwaan, M., Egert, S., Fritsche, A., Gerlach, S., Hauner, H., Heseker, H., Koletzko, B., Dirk, Müller-Wieland, Schulze, M., Virmani, K., Watzl, B., & Buyken, A. (2019). Quantitative recommendation on sugar intake in Germany Short version of the consensus paper by the German Obesity Society ( DAG ) , German Diabetes Society ( DDG ) and German Nutrition Society ( DGE ).

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96 Valeur J, Småstuen MC, Knudsen T, Lied GA, Røseth AG. Exploring Gut Microbiota Composition as an Indicator of Clinical Response to Dietary FODMAP Restriction in Patients with Irritable Bowel Syndrome. Dig Dis Sci. 2018 Feb;63(2):429-436. doi: 10.1007/s10620-017-4893-3. Epub 2018 Jan 4. PMID: 29302878.

 

Kapitel 5: So machen Sie Ihre FODMAP-arme Mittelmeerernährung noch effektiver und sicherer

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22 Britto S, Kellermayer R. Carbohydrate Monotony as Protection and Treatment for Inflammatory Bowel Disease. J Crohns Colitis. 2019 Jul 25;13(7):942-948. doi: 10.1093/ecco-jcc/jjz011. PMID: 30715243.

23 Konijeti GG, Kim N, Lewis JD, Groven S, Chandrasekaran A, Grandhe S, Diamant C, Singh E, Oliveira G, Wang X, Molparia B, Torkamani A. Efficacy of the Autoimmune Protocol Diet for Inflammatory Bowel Disease. Inflamm Bowel Dis. 2017 Nov;23(11):2054-2060. doi: 10.1097/MIB.0000000000001221. PMID: 28858071; PMCID: PMC5647120.

24 Barone M, Turroni S, Rampelli S, Soverini M, D'Amico F, Biagi E, Brigidi P, Troiani E, Candela M. Gut microbiome response to a modern Paleolithic diet in a Western lifestyle context. PLoS One. 2019 Aug 8;14(8):e0220619. doi: 10.1371/journal.pone.0220619. PMID: 31393934; PMCID: PMC6687155.

25 Gibson PR, Shepherd SJ. Personal view: food for thought--western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis. Aliment Pharmacol Ther. 2005 Jun 15;21(12):1399-409. doi: 10.1111/j.1365-2036.2005.02506.x. PMID: 15948806.

 

26 Kosulwat V. The nutrition and health transition in Thailand. Public Health Nutr. 2002 Feb;5(1A):183-9. doi: 10.1079/PHN2001292. PMID: 12027283.

 

Kapitel 6: Wenn die mediterrane Low-FODMAP-Diät nicht funktioniert

1 Wilson B, Cox SR, Whelan K. Challenges of the low FODMAP diet for managing irritable bowel syndrome and approaches to their minimisation and mitigation. Proc Nutr Soc. 2021 Feb;80(1):19-28. doi: 10.1017/S0029665120006990. Epub 2020 May 29. PMID: 32468985.

2 Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014 Jun;46(3):225-40. doi: 10.1007/s12016-012-8339-6. PMID: 23229594.

3 Mekkel G, Barta Z, Ress Z, Gyimesi E, Sipka S, Zeher M. [Increased IgE-type antibody response to food allergens in irritable bowel syndrome and inflammatory bowel diseases]. Orv Hetil. 2005 Apr 24;146(17):797-802. Hungarian. PMID: 17918636.

4 Bischoff SC, Mayer J, Wedemeyer J, Meier PN, Zeck-Kapp G, Wedi B, Kapp A, Cetin Y, Gebel M, Manns MP. Colonoscopic allergen provocation (COLAP): a new diagnostic approach for gastrointestinal food allergy. Gut. 1997 Jun;40(6):745-53. doi: 10.1136/gut.40.6.745. PMID: 9245928; PMCID: PMC1027199.

5 Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut. 2004 Oct;53(10):1459-64. doi: 10.1136/gut.2003.037697. PMID: 15361495; PMCID: PMC1774223.

6 Ostrowska L, Wasiluk D, Lieners CFJ, Gałęcka M, Bartnicka A, Tveiten D. Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS-Results from an Open Label Study. J Clin Med. 2021 Sep 23;10(19):4317. doi: 10.3390/jcm10194317. PMID: 34640335; PMCID: PMC8509634.

7 Setinova, I., Havranova, M., Dankova, E., & Vorlickova, M. (2015). Diagnostic value of the lymphocyte transformation test for non-IgE mediated food allergy. Clinical and Translational Allergy, 5(Suppl 3), P31. https://doi.org/10.1186/2045-7022-5-S3-P31.

8 Schwab D, Raithel M, Klein P, Winterkamp S, Weidenhiller M, Radespiel-Troeger M, Hochberger J, Hahn EG. Immunoglobulin E and eosinophilic cationic protein in segmental lavage fluid of the small and large bowel identify patients with food allergy. Am J Gastroenterol. 2001 Feb;96(2):508-14. doi: 10.1111/j.1572-0241.2001.03467.x. PMID: 11232698.

9 Aguilera-Lizarraga J, Florens M, Hussein H, Boeckxstaens G. Local immune response as novel disease mechanism underlying abdominal pain in patients with irritable bowel syndrome. Acta Clin Belg. 2021 Oct 28:1-8. doi: 10.1080/17843286.2021.1996069. Epub ahead of print. PMID: 34709996.

10 Ahlström MG, Thyssen JP, Menné T, Johansen JD. Prevalence of nickel allergy in Europe following the EU Nickel Directive – a review. Contact Dermatitis. 2017 Oct;77(4):193-200. doi: 10.1111/cod.12846. Epub 2017 Jul 21. PMID: 28730624.

11 Ricciardi L, Arena A, Arena E, Zambito M, Ingrassia A, Valenti G, Loschiavo G, D'Angelo A, Saitta S. Systemic nickel allergy syndrome: epidemiological data from four Italian allergy units. Int J Immunopathol Pharmacol. 2014 Jan-Mar;27(1):131-6. doi: 10.1177/039463201402700118. PMID: 24674689.

12 Heyman M. Gut barrier dysfunction in food allergy. Eur J Gastroenterol Hepatol. 2005 Dec;17(12):1279-85. doi: 10.1097/00042737-200512000-00003. PMID: 16292078.

13 Kageyama Y, Aida K, Kawauchi K, Morimoto M, Akiyama T, Nakamura T. Higher incidence of zinc and nickel hypersensitivity in patients with irritable bowel syndrome. Immun Inflamm Dis. 2019 Dec;7(4):304-307. doi: 10.1002/iid3.274. Epub 2019 Oct 24. PMID: 31647193; PMCID: PMC6842818.

14 Rizzi A, Nucera E, Laterza L, Gaetani E, Valenza V, Corbo GM, Inchingolo R, Buonomo A, Schiavino D, Gasbarrini A. Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet? J Neurogastroenterol Motil. 2017 Jan 30;23(1):101-108. doi: 10.5056/jnm16027. PMID: 28049864; PMCID: PMC5216640.

15 Ständer S, Oppel E, Thomas P, Summer B. Evaluation of lymphocyte transformation tests as compared with patch tests in nickel allergy diagnosis. Contact Dermatitis. 2017 Apr;76(4):228-234. doi: 10.1111/cod.12751. Epub 2017 Feb 7. PMID: 28176340.

16 Austin GL, Dalton CB, Hu Y, Morris CB, Hankins J, Weinland SR, Westman EC, Yancy WS Jr, Drossman DA. A very low-carbohydrate diet improves symptoms and quality of life in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol. 2009 Jun;7(6):706-708.e1. doi: 10.1016/j.cgh.2009.02.023. Epub 2009 Mar 10. PMID: 19281859; PMCID: PMC2693479.

17 Dwyer DD, Darville RL. Specific Carbohydrate Diet: Irritable Bowel Syndrome patient case study. Nutrition & Food Science. 45(6). doi: 10.1108/NFS-05-2015-0056.

18 Ohlsson B. Theories behind the effect of starch  and sucrose reduced diets on gastrointestinal symptoms in irritable bowel syndrome (Review). Mol Med Rep. 2021 Oct;24(4):732. doi: 10.3892/mmr.2021.12372. Epub 2021 Aug 20. PMID: 34414452; PMCID: PMC8404103.

19 Garcia-Etxebarria K, Zheng T, Bonfiglio F, Bujanda L, Dlugosz A, Lindberg G, Schmidt PT, Karling P, Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Jonkers D, Eswaran S, Chey WD, Kashyap P, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, D'Amato M. Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients. Clin Gastroenterol Hepatol. 2018 Oct;16(10):1673-1676. doi: 10.1016/j.cgh.2018.01.047. Epub 2018 Feb 21. PMID: 29408290; PMCID: PMC6103908.

20 Kim SB, Calmet FH, Garrido J, Garcia-Buitrago MT, Moshiree B. Sucrase-Isomaltase Deficiency as a Potential Masquerader in Irritable Bowel Syndrome. Dig Dis Sci. 2020 Feb;65(2):534-540. doi: 10.1007/s10620-019-05780-7. Epub 2019 Sep 6. PMID: 31493040.

21 Nilholm C, Roth B, Ohlsson B. A Dietary Intervention with Reduction of Starch and Sucrose Leads to Reduced Gastrointestinal and Extra-Intestinal Symptoms in IBS Patients. Nutrients. 2019 Jul 20;11(7):1662. doi: 10.3390/nu11071662. PMID: 31330810; PMCID: PMC6682926.

22 Craig C. Mitoprotective dietary approaches for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Caloric restriction, fasting, and ketogenic diets. Med Hypotheses. 2015 Nov;85(5):690-3. doi: 10.1016/j.mehy.2015.08.013. Epub 2015 Aug 21. PMID: 26315446.

23 Nakamura S, Hisamura R, Shimoda S, Shibuya I, Tsubota K. Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate. Nutr Metab (Lond). 2014 Aug 28;11:40. doi: 10.1186/1743-7075-11-40. PMID: 25302070; PMCID: PMC4190937.

24 Ford RP, Barnes GL. Breath hydrogen test and sucrase isomaltase deficiency. Arch Dis Child. 1983 Aug;58(8):595-7. doi: 10.1136/adc.58.8.595. PMID: 6614973; PMCID: PMC1628322.

25 Slattery SA, Niaz O, Aziz Q, Ford AC, Farmer AD. Systematic review with meta-analysis: the prevalence of bile acid malabsorption in the irritable bowel syndrome with diarrhoea. Aliment Pharmacol Ther. 2015 Jul;42(1):3-11. doi: 10.1111/apt.13227. Epub 2015 Apr 27. PMID: 25913530.

26 Westergaard H. Bile Acid malabsorption. Curr Treat Options Gastroenterol. 2007 Feb;10(1):28-33. doi: 10.1007/s11938-007-0054-7. PMID: 17298762.

27 Dukowicz AC, Lacy BE, Levine GM. Small intestinal bacterial overgrowth: a comprehensive review. Gastroenterol Hepatol (N Y). 2007 Feb;3(2):112-22. PMID: 21960820; PMCID: PMC3099351.

28 Sagar NM, Duboc H, Kay GL, Alam MT, Wicaksono AN, Covington JA, Quince C, Kokkorou M, Svolos V, Palmieri LJ, Gerasimidis K, Walters JRF, Arasaradnam RP. The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids. Sci Rep. 2020 Nov 24;10(1):20436. doi: 10.1038/s41598-020-77374-7. PMID: 33235223; PMCID: PMC7686486.

29 Camilleri M. Bile Acid diarrhea: prevalence, pathogenesis, and therapy. Gut Liver. 2015 May 23;9(3):332-9. doi: 10.5009/gnl14397. PMID: 25918262; PMCID: PMC4413966.

30 Jackson A, Lalji A, Kabir M, Muls A, Gee C, Vyoral S, Shaw C, Andreyev HJN. The efficacy of a low-fat diet to manage the symptoms of bile acid malabsorption – outcomes in patients previously treated for cancer. Clin Med (Lond). 2017 Oct;17(5):412-418. doi: 10.7861/clinmedicine.17-5-412. PMID: 28974589; PMCID: PMC6301937.

31 Costa S, Gattoni S, Nicolardi ML, Costetti M, Maimaris S, Schiepatti A, Biagi F. Prevalence and clinical features of bile acid diarrhea in patients with chronic diarrhea. J Dig Dis. 2021 Feb;22(2):108-112. doi: 10.1111/1751-2980.12969. Epub 2021 Feb 3. PMID: 33438795.

32 Sciarretta G, Furno A, Mazzoni M, Malaguti P. Post-cholecystectomy diarrhea: evidence of bile acid malabsorption assessed by SeHCAT test. Am J Gastroenterol. 1992 Dec;87(12):1852-4. PMID: 1449156.

33 Vijayvargiya P, Busciglio I, Burton D, Donato L, Lueke A, Camilleri M. Bile Acid Deficiency in a Subgroup of Patients With Irritable Bowel Syndrome With Constipation Based on Biomarkers in Serum and Fecal Samples. Clin Gastroenterol Hepatol. 2018 Apr;16(4):522-527. doi: 10.1016/j.cgh.2017.06.039. Epub 2017 Jun 27. PMID: 28666948; PMCID: PMC5745308.

34 Eswaran S, Guentner A, Chey WD. Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation. J Neurogastroenterol Motil. 2014 Apr 30;20(2):141-51. doi: 10.5056/jnm.2014.20.2.141. PMID: 24840367; PMCID: PMC4015201.

35 Perbtani Y, Forsmark CE. Update on the diagnosis and management of exocrine pancreatic insufficiency. F1000Res. 2019 Nov 26;8:F1000 Faculty Rev-1991. doi: 10.12688/f1000research.20779.1. PMID: 31824646; PMCID: PMC6880257.

36 Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, Morley S, Sanders DS. Some patients with irritable bowel syndrome may have exocrine pancreatic insufficiency. Clin Gastroenterol Hepatol. 2010 May;8(5):433-8. doi: 10.1016/j.cgh.2009.09.032. Epub 2009 Oct 14. PMID: 19835990.

37 Hart PA, Conwell DL. Diagnosis of Exocrine Pancreatic Insufficiency. Curr Treat Options Gastroenterol. 2015 Sep;13(3):347-53. doi: 10.1007/s11938-015-0057-8. PMID: 26077487.

38 Baenkler HW. Salicylate intolerance: pathophysiology, clinical spectrum, diagnosis and treatment. Dtsch Arztebl Int. 2008 Feb;105(8):137-42. doi: 10.3238/arztebl.2008.0137. Epub 2008 Feb 22. PMID: 19633779; PMCID: PMC2696737.

39 Raithel M, Baenkler HW, Naegel A, Buchwald F, Schultis HW, Backhaus B, Kimpel S, Koch H, Mach K, Hahn EG, Konturek PC. Significance of salicylate intolerance in diseases of the lower gastrointestinal tract. J Physiol Pharmacol. 2005 Sep;56 Suppl 5:89-102. PMID: 16247191.

40 Tuck CJ, Malakar S, Barrett JS, Muir JG, Gibson PR. Naturally-occurring dietary salicylates in the genesis of functional gastrointestinal symptoms in patients with irritable bowel syndrome: Pilot study. JGH Open. 2021 Jul 21;5(8):871-878. doi: 10.1002/jgh3.12578. PMID: 34386594; PMCID: PMC8341183.

41 Velten FW, Bayerl C, Baenkler HW, Schaefer D. Functional eicosanoid test and typing (FET) in acetylsalicylic acid intolerant patients with urticaria. J Physiol Pharmacol. 2006 Dec;57 Suppl 12:35-46. PMID: 17244953.

42 Hare LG, Woodside JV, Young IS. Dietary salicylates. J Clin Pathol. 2003 Sep;56(9):649-50. doi: 10.1136/jcp.56.9.649. PMID: 12944545; PMCID: PMC1770049.

43 Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, Latorre-Moratalla M, Vidal-Carou MDC. Histamine Intolerance: The Current State of the Art. Biomolecules. 2020 Aug 14;10(8):1181. doi: 10.3390/biom10081181. PMID: 32824107; PMCID: PMC7463562.

44 Wöhrl S, Hemmer W, Focke M, Rappersberger K, Jarisch R. Histamine intolerance-like symptoms in healthy volunteers after oral provocation with liquid histamine. Allergy Asthma Proc. 2004 Sep-Oct;25(5):305-11. PMID: 15603203.

45 Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007 May;85(5):1185-96. doi: 10.1093/ajcn/85.5.1185. PMID: 17490952.

46 Befani O, Shiozaki TS, Turini P, Gerosa P, Mondovi B. Inhibition of diamine oxidase activity by metronidazole. Biochem Biophys Res Commun. 1995 Jul 17;212(2):589-94. doi: 10.1006/bbrc.1995.2010. PMID: 7626074.

47 Schmidt WU, Sattler J, Hesterberg R, Röher HD, Zoedler T, Sitter H, Lorenz W. Human intestinal diamine oxidase (DAO) activity in Crohn's disease: a new marker for disease assessment? Agents Actions. 1990 Apr;30(1-2):267-70. doi: 10.1007/BF01969057. PMID: 2115243.

48 Rosell-Camps A, Zibetti S, Pérez-Esteban G, Vila-Vidal M, Ferrés-Ramis L, García-Teresa-García E. Histamine intolerance as a cause of chronic digestive complaints in pediatric patients. Rev Esp Enferm Dig. 2013 Apr;105(4):201-6. doi: 10.4321/s1130-01082013000400004. PMID: 23859448.

49 San Mauro Martin I, Brachero S, Garicano Vilar E. Histamine intolerance and dietary management: A complete review. Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):475-83. doi: 10.1016/j.aller.2016.04.015. Epub 2016 Aug 31. PMID: 27590961.

50 Schnedl WJ, Schenk M, Lackner S, Enko D, Mangge H, Forster F. Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Sci Biotechnol. 2019 May 24;28(6):1779-1784. doi: 10.1007/s10068-019-00627-3. PMID: 31807350; PMCID: PMC6859183.

51 Schnedl WJ, Enko D. Histamine Intolerance Originates in the Gut. Nutrients. 2021 Apr 12;13(4):1262. doi: 10.3390/nu13041262. PMID: 33921522; PMCID: PMC8069563.

52 Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, Wirtz S, Neurath MF, Zopf Y. Microbial patterns in patients with histamine intolerance. J Physiol Pharmacol. 2018 Aug;69(4). doi: 10.26402/jpp.2018.4.09. Epub 2018 Dec 9. PMID: 30552302.

53 Miyoshi M, Ueno M, Matsuo M, Hamada Y, Takahashi M, Yamamoto M, Yamamoto I, Mikajiri R, Tabuchi S, Wakida K, Yamanishi M, Hirai M, Usami M. Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women. Nutrition. 2017 Jul-Aug;39-40:67-70. doi: 10.1016/j.nut.2017.03.004. Epub 2017 Mar 28. PMID: 28606572.

 

54 Fukudome I, Kobayashi M, Dabanaka K, Maeda H, Okamoto K, Okabayashi T, Baba R, Kumagai N, Oba K, Fujita M, Hanazaki K. Diamine oxidase as a marker of intestinal mucosal injury and the effect of soluble dietary fiber on gastrointestinal tract toxicity after intravenous 5-fluorouracil treatment in rats. Med Mol Morphol. 2014 Jun;47(2):100-7. doi: 10.1007/s00795-013-0055-7. Epub 2013 Sep 5. PMID: 24005798.

 

Kapitel 7: Regelmäßiges Fasten - die verkannte Wunderwaffe

1 Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019 Mar 5;26(10):2704-2719.e6. doi: 10.1016/j.celrep.2019.02.019. PMID: 30840892; PMCID: PMC6528490.

2 Song S, Bai M, Ling Z, Lin Y, Wang S, Chen Y. Intermittent administration of a fasting-mimicking diet reduces intestinal inflammation and promotes repair to ameliorate inflammatory bowel disease in mice. J Nutr Biochem. 2021 Oct;96:108785. doi: 10.1016/j.jnutbio.2021.108785. Epub 2021 Jun 1. PMID: 34087411.

3 Nakamura S, Hisamura R, Shimoda S, Shibuya I, Tsubota K. Fasting mitigates immediate hypersensitivity: a pivotal role of endogenous D-beta-hydroxybutyrate. Nutr Metab (Lond). 2014 Aug 28;11:40. doi: 10.1186/1743-7075-11-40. PMID: 25302070; PMCID: PMC4190937.

4 Kanazawa M, Fukudo S. Effects of fasting therapy on irritable bowel syndrome. Int J Behav Med. 2006;13(3):214-20. doi: 10.1207/s15327558ijbm1303_4. PMID: 17078771.

5 Longo VD, Panda S. Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan. Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. PMID: 27304506; PMCID: PMC5388543.

6 Longo VD, Mattson MP. Fasting: molecular mechanisms and clinical applications. Cell Metab. 2014 Feb 4;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. Epub 2014 Jan 16. PMID: 24440038; PMCID: PMC3946160.

7 Johnson JB, John S, Laub DR. Pretreatment with alternate day modified fast will permit higher dose and frequency of cancer chemotherapy and better cure rates. Med Hypotheses. 2009 Apr;72(4):381-2. doi: 10.1016/j.mehy.2008.07.064. Epub 2009 Jan 9. PMID: 19135806.

8 Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease. Endocr Rev. 2018 Aug 1;39(4):489-517. doi: 10.1210/er.2017-00211. PMID: 29697773; PMCID: PMC6093334.

9 Goodpaster BH, Sparks LM. Metabolic Flexibility in Health and Disease. Cell Metab. 2017 May 2;25(5):1027-1036. doi: 10.1016/j.cmet.2017.04.015. PMID: 28467922; PMCID: PMC5513193.

10 Dedual MA, Wueest S, Borsigova M, Konrad D. Intermittent fasting improves metabolic flexibility in short-term high-fat diet-fed mice. Am J Physiol Endocrinol Metab. 2019 Nov 1;317(5):E773-E782. doi: 10.1152/ajpendo.00187.2019. Epub 2019 Sep 10. PMID: 31503513.

11 Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014. Erratum in: Cell Stem Cell. 2016 Feb 4;18(2):291-2. PMID: 24905167; PMCID: PMC4102383.

12 Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18. PMID: 26094889; PMCID: PMC4509734.

13 Zhang X, Zou Q, Zhao B, Zhang J, Zhao W, Li Y, Liu R, Liu X, Liu Z. Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders. Redox Biol. 2020 May;32:101535. doi: 10.1016/j.redox.2020.101535. Epub 2020 Apr 10. Erratum in: Redox Biol. 2021 Aug;44:101955. PMID: 32305005; PMCID: PMC7162980.

14 Charlot A, Hutt F, Sabatier E, Zoll J. Beneficial Effects of Early Time-Restricted Feeding on Metabolic Diseases: Importance of Aligning Food Habits with the Circadian Clock. Nutrients. 2021 Apr 22;13(5):1405. doi: 10.3390/nu13051405. PMID: 33921979; PMCID: PMC8143522.

15 Lewin R. Man the Scavenger: Hominids of 2 million years ago ate meat: but were they hunters or scavengers? A scavenging hypothesis has now been fully articulated. Science. 1984 May 25;224(4651):861-2. doi: 10.1126/science.224.4651.861. PMID: 17743189.

16 Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016 Jun 7;15(10):2136-2146. doi: 10.1016/j.celrep.2016.05.009. Epub 2016 May 26. PMID: 27239035; PMCID: PMC4899145.

17 Mesnage R, Grundler F, Schwiertz A, Le Maho Y, Wilhelmi de Toledo F. Changes in human gut microbiota composition are linked to the energy metabolic switch during 10 d of Buchinger fasting. J Nutr Sci. 2019 Nov 12;8:e36. doi: 10.1017/jns.2019.33. PMID: 31798864; PMCID: PMC6861737.

18 Sadeghian M, Hosseini SA, Zare Javid A, Ahmadi Angali K, Mashkournia A. Effect of Fasting-Mimicking Diet or Continuous Energy Restriction on Weight Loss, Body Composition, and Appetite-Regulating Hormones Among Metabolically Healthy Women with Obesity: a Randomized Controlled, Parallel Trial. Obes Surg. 2021 May;31(5):2030-2039. doi: 10.1007/s11695-020-05202-y. Epub 2021 Jan 9. PMID: 33420673.

19 Wilhelmi de Toledo F, Buchinger A, Burggrabe H, Hölz G, Kuhn C, Lischka E, Lischka N, Lützner H, May W, Ritzmann-Widderich M, Stange R, Wessel A, Boschmann M, Peper E, Michalsen A; Medical Association for Fasting and Nutrition (Ärztegesellschaft für Heilfasten und Ernährung, ÄGHE. Fasting therapy – an expert panel update of the 2002 consensus guidelines. Forsch Komplementmed. 2013;20(6):434-43. doi: 10.1159/000357602. Epub 2013 Dec 16. PMID: 24434758.

20 Rajpal A, Ismail-Beigi F. Intermittent fasting and 'metabolic switch': Effects on metabolic syndrome, prediabetes and type 2 diabetes. Diabetes Obes Metab. 2020 Sep;22(9):1496-1510. doi: 10.1111/dom.14080. Epub 2020 Jun 3. PMID: 32372521.

21 Finnell JS, Saul BC, Goldhamer AC, Myers TR. Is fasting safe? A chart review of adverse events during medically supervised, water-only fasting. BMC Complement Altern Med. 2018 Feb 20;18(1):67. doi: 10.1186/s12906-018-2136-6. PMID: 29458369; PMCID: PMC5819235.

22 Mehanna HM, Moledina J, Travis J. Refeeding syndrome: what it is, and how to prevent and treat it. BMJ. 2008 Jun 28;336(7659):1495-8. doi: 10.1136/bmj.a301. PMID: 18583681; PMCID: PMC2440847.

 

23 Babic T, Browning KN. The role of vagal neurocircuits in the regulation of nausea and vomiting. Eur J Pharmacol. 2014 Jan 5;722:38-47. doi: 10.1016/j.ejphar.2013.08.047. Epub 2013 Oct 31. PMID: 24184670; PMCID: PMC3893663.

 

Kapitel 8: Feintuning für bestes Wohlbefinden: Der darmgesunde Lebensstil

1 Davis S. Reversal of Irritable Bowel Syndrome, Sleep Disturbance, and Fatigue With an Elimination Diet, Lifestyle Modification, and Dietary Supplements: A Case Report. Integr Med (Encinitas). 2016 Oct;15(5):60-66. PMID: 27980496; PMCID: PMC5145014.

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93 Jensen MP, Adachi T, Tomé-Pires C, Lee J, Osman ZJ, Miró J. Mechanisms of hypnosis: toward the development of a biopsychosocial model. Int J Clin Exp Hypn. 2015;63(1):34-75. doi: 10.1080/00207144.2014.961875. Erratum in: Int J Clin Exp Hypn. 2015;63(2):247. PMID: 25365127; PMCID: PMC4220267.

94 Häuser W, Hagl M, Schmierer A, Hansen E. The Efficacy, Safety and Applications of Medical Hypnosis. Dtsch Arztebl Int. 2016 Apr 29;113(17):289-96. doi: 10.3238/arztebl.2016.0289. PMID: 27173407; PMCID: PMC4873672.

95 Whorwell PJ, Prior A, Colgan SM. Hypnotherapy in severe irritable bowel syndrome: further experience. Gut. 1987 Apr;28(4):423-5. doi: 10.1136/gut.28.4.423. PMID: 3583070; PMCID: PMC1432815.

96 Gonsalkorale WM. Gut-directed hypnotherapy: the Manchester approach for treatment of irritable bowel syndrome. Int J Clin Exp Hypn. 2006 Jan;54(1):27-50. doi: 10.1080/00207140500323030. PMID: 16316882.

97 Gonsalkorale WM. Gut-directed hypnotherapy: the Manchester approach for treatment of irritable bowel syndrome. Int J Clin Exp Hypn. 2006 Jan;54(1):27-50. doi: 10.1080/00207140500323030. PMID: 16316882.

98 Peters SL, Yao CK, Philpott H, Yelland GW, Muir JG, Gibson PR. Randomised clinical trial: the efficacy of gut-directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome. Aliment Pharmacol Ther. 2016 Sep;44(5):447-59. doi: 10.1111/apt.13706. Epub 2016 Jul 11. PMID: 27397586.

99 Rutten JMTM, Vlieger AM, Frankenhuis C, George EK, Groeneweg M, Norbruis OF, Tjon A Ten W, van Wering HM, Dijkgraaf MGW, Merkus MP, Benninga MA. Home-Based Hypnotherapy Self-exercises vs Individual Hypnotherapy With a Therapist for Treatment of Pediatric Irritable Bowel Syndrome, Functional Abdominal Pain, or Functional Abdominal Pain Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2017 May 1;171(5):470-477. doi: 10.1001/jamapediatrics.2017.0091. PMID: 28346581.

100 Palsson OS, Turner MJ, Whitehead WE. Hypnosis home treatment for irritable bowel syndrome: a pilot study. Int J Clin Exp Hypn. 2006 Jan;54(1):85-99. doi: 10.1080/00207140500328666. PMID: 16316885.

101 Stanculete MF, Matu S, Pojoga C, Dumitrascu DL. Coping strategies and irrational beliefs as mediators of the health-related quality of life impairments in irritable bowel syndrome. J Gastrointestin Liver Dis. 2015 Jun;24(2):159-64. doi: 10.15403/jgld.2014.1121.242.strt. PMID: 26114174.

102 Muscatello MR, Bruno A, Scimeca G, Pandolfo G, Zoccali RA. Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome. World J Gastroenterol. 2014 Jun 28;20(24):7570-86. doi: 10.3748/wjg.v20.i24.7570. PMID: 24976697; PMCID: PMC4069288.

103 Blankstein U, Chen J, Diamant NE, Davis KD. Altered brain structure in irritable bowel syndrome: potential contributions of pre-existing and disease-driven factors. Gastroenterology. 2010 May;138(5):1783-9. doi: 10.1053/j.gastro.2009.12.043. Epub 2010 Jan 4. PMID: 20045701.

104 Claassen J, Labrenz F, Ernst TM, Icenhour A, Langhorst J, Forsting M, Timmann D, Elsenbruch S. Altered Cerebellar Activity in Visceral Pain-Related Fear Conditioning in Irritable Bowel Syndrome. Cerebellum. 2017 Apr;16(2):508-517. doi: 10.1007/s12311-016-0832-7. PMID: 27797090.

105 Li L, Xiong L, Zhang S, Yu Q, Chen M. Cognitive-behavioral therapy for irritable bowel syndrome: a meta-analysis. J Psychosom Res. 2014 Jul;77(1):1-12. doi: 10.1016/j.jpsychores.2014.03.006. Epub 2014 Mar 26. PMID: 24913335.

106 Hunt M, Miguez S, Dukas B, Onwude O, White S. Efficacy of Zemedy, a Mobile Digital Therapeutic for the Self-management of Irritable Bowel Syndrome: Crossover Randomized Controlled Trial. JMIR Mhealth Uhealth. 2021 May 20;9(5):e26152. doi: 10.2196/26152. PMID: 33872182; PMCID: PMC8176342.

 

107 Schulz E, Stankewitz A, Witkovský V, Winkler AM, Tracey I. Strategy-dependent modulation of cortical pain circuits for the attenuation of pain. Cortex. 2019 Apr;113:255-266. doi: 10.1016/j.cortex.2018.12.014. Epub 2019 Jan 4. PMID: 30711854.

 

Kapitel 9: Wenn Eigeninitiative an ihre Grenzen stößt

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2 Dimidi E, Whelan K. Food supplements and diet as treatment options in irritable bowel syndrome. Neurogastroenterol Motil. 2020 Aug;32(8):e13951. doi: 10.1111/nmo.13951. PMID: 32697018.

3 Asha MZ, Khalil SFH. Efficacy and Safety of Probiotics, Prebiotics and Synbiotics in the Treatment of Irritable Bowel Syndrome: A systematic review and meta-analysis. Sultan Qaboos Univ Med J. 2020 Feb;20(1):e13-e24. doi: 10.18295/squmj.2020.20.01.003. Epub 2020 Mar 9. PMID: 32190365; PMCID: PMC7065695.

4 Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of action. Ann Nutr Metab. 2012;61(2):160-74. doi: 10.1159/000342079. Epub 2012 Oct 2. PMID: 23037511.

5 de Simone C. The Unregulated Probiotic Market. Clin Gastroenterol Hepatol. 2019 Apr;17(5):809-817. doi: 10.1016/j.cgh.2018.01.018. Epub 2018 Mar 14. PMID: 29378309.

6 Rao SSC, Rehman A, Yu S, Andino NM. Brain fogginess, gas and bloating: a link between SIBO, probiotics and metabolic acidosis. Clin Transl Gastroenterol. 2018 Jun 19;9(6):162. doi: 10.1038/s41424-018-0030-7. PMID: 29915215; PMCID: PMC6006167.

7 Hrubisko M, Danis R, Huorka M, Wawruch M. Histamine Intolerance-The More We Know the Less We Know. A Review. Nutrients. 2021 Jun 29;13(7):2228. doi: 10.3390/nu13072228. PMID: 34209583; PMCID: PMC8308327.

8 Sisson G, Ayis S, Sherwood RA, Bjarnason I. Randomised clinical trial: A liquid multi-strain probiotic vs. placebo in the irritable bowel syndrome--a 12 week double-blind study. Aliment Pharmacol Ther. 2014 Jul;40(1):51-62. doi: 10.1111/apt.12787. Epub 2014 May 11. PMID: 24815298.

9 Lyra A, Hillilä M, Huttunen T, Männikkö S, Taalikka M, Tennilä J, Tarpila A, Lahtinen S, Ouwehand AC, Veijola L. Irritable bowel syndrome symptom severity improves equally with probiotic and placebo. World J Gastroenterol. 2016 Dec 28;22(48):10631-10642. doi: 10.3748/wjg.v22.i48.10631. PMID: 28082816; PMCID: PMC5192275.

10 Camilleri M. Management Options for Irritable Bowel Syndrome. Mayo Clin Proc. 2018 Dec;93(12):1858-1872. doi: 10.1016/j.mayocp.2018.04.032. PMID: 30522596; PMCID: PMC6314474.

11 Skrzydło-Radomańska B, Prozorow-Król B, Cichoż-Lach H, Majsiak E, Bierła JB, Kanarek E, Sowińska A, Cukrowska B. The Effectiveness and Safety of Multi-Strain Probiotic Preparation in Patients with Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized Controlled Study. Nutrients. 2021 Feb 26;13(3):756. doi: 10.3390/nu13030756. PMID: 33652763; PMCID: PMC7996889.

12 Ki Cha B, Mun Jung S, Hwan Choi C, Song ID, Woong Lee H, Joon Kim H, Hyuk J, Kyung Chang S, Kim K, Chung WS, Seo JG. The effect of a multispecies probiotic mixture on the symptoms and fecal microbiota in diarrhea-dominant irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Gastroenterol. 2012 Mar;46(3):220-7. doi: 10.1097/MCG.0b013e31823712b1. PMID: 22157240.

13 Alammar N, Wang L, Saberi B, Nanavati J, Holtmann G, Shinohara RT, Mullin GE. The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data. BMC Complement Altern Med. 2019 Jan 17;19(1):21. doi: 10.1186/s12906-018-2409-0. PMID: 30654773; PMCID: PMC6337770.

14 Chumpitazi BP, Kearns GL, Shulman RJ. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders. Aliment Pharmacol Ther. 2018 Mar;47(6):738-752. doi: 10.1111/apt.14519. Epub 2018 Jan 26. PMID: 29372567; PMCID: PMC5814329.

15 Salaritabar A, Darvishi B, Hadjiakhoondi F, Manayi A, Sureda A, Nabavi SF, Fitzpatrick LR, Nabavi SM, Bishayee A. Therapeutic potential of flavonoids in inflammatory bowel disease: A comprehensive review. World J Gastroenterol. 2017 Jul 28;23(28):5097-5114. doi: 10.3748/wjg.v23.i28.5097. PMID: 28811706; PMCID: PMC5537178.

16 Qin HY, Zang KH, Zuo X, Wu XA, Bian ZX. Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon. J Med Food. 2019 Jul;22(7):663-671. doi: 10.1089/jmf.2018.4264. Epub 2019 Mar 28. PMID: 30920336.

17 Jia H, Zhang Y, Si X, Jin Y, Jiang D, Dai Z, Wu Z. Quercetin Alleviates Oxidative Damage by Activating Nuclear Factor Erythroid 2-Related Factor 2 Signaling in Porcine Enterocytes. Nutrients. 2021 Jan 26;13(2):375. doi: 10.3390/nu13020375. PMID: 33530513; PMCID: PMC7911945.

18 Weng Z, Zhang B, Asadi S, Sismanopoulos N, Butcher A, Fu X, Katsarou-Katsari A, Antoniou C, Theoharides TC. Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS One. 2012;7(3):e33805. doi: 10.1371/journal.pone.0033805. Epub 2012 Mar 28. PMID: 22470478; PMCID: PMC3314669.

19 Roudsari NM, Lashgari NA, Momtaz S, Farzaei MH, Marques AM, Abdolghaffari AH. Natural polyphenols for the prevention of irritable bowel syndrome: molecular mechanisms and targets; a comprehensive review. Daru. 2019 Dec;27(2):755-780. doi: 10.1007/s40199-019-00284-1. Epub 2019 Jul 4. PMID: 31273572; PMCID: PMC6895345.

20 Stromsnes K, Mas-Bargues C, Gambini J, Gimeno-Mallench L. Protective Effects of Polyphenols Present in Mediterranean Diet on Endothelial Dysfunction. Oxid Med Cell Longev. 2020 Aug 6;2020:2097096. doi: 10.1155/2020/2097096. PMID: 32831990; PMCID: PMC7428938.

21 Di Pierro F, Derosa G, Maffioli P, Bertuccioli A, Togni S, Riva A, Allegrini P, Khan A, Khan S, Khan BA, Altaf N, Zahid M, Ujjan ID, Nigar R, Khushk MI, Phulpoto M, Lail A, Devrajani BR, Ahmed S. Possible Therapeutic Effects of Adjuvant Quercetin Supplementation Against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study. Int J Gen Med. 2021 Jun 8;14:2359-2366. doi: 10.2147/IJGM.S318720. PMID: 34135619; PMCID: PMC8197660.

22 Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods. 2017 Oct 22;6(10):92. doi: 10.3390/foods6100092. PMID: 29065496; PMCID: PMC5664031.

23 Atefi M, Darand M, Entezari MH, Jamialahmadi T, Bagherniya M, Sahebkar A. A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases. Adv Exp Med Biol. 2021;1291:295-326. doi: 10.1007/978-3-030-56153-6_18. PMID: 34331698.

24 Bundy R, Walker AF, Middleton RW, Booth J. Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study. J Altern Complement Med. 2004 Dec;10(6):1015-8. doi: 10.1089/acm.2004.10.1015. PMID: 15673996.

25 Brenner DM, Sayuk GS, Gutman CR, Jo E, Elmes SJR, Liu LWC, Cash BD. Efficacy and Safety of Eluxadoline in Patients With Irritable Bowel Syndrome With Diarrhea Who Report Inadequate Symptom Control With Loperamide: RELIEF Phase 4 Study. Am J Gastroenterol. 2019 Sep;114(9):1502-1511. doi: 10.14309/ajg.0000000000000327. PMID: 31356229; PMCID: PMC6738625.

26 Brenner DM, Sayuk GS, Abel JL, Burslem K. Improved work productivity and health-related quality of life in patients with irritable bowel syndrome with diarrhea receiving eluxadoline following inadequate response to loperamide. J Manag Care Spec Pharm. 2021 Apr;27(4):469-477. PMID: 33769858.

27 Lobo B, Ramos L, Martínez C, Guilarte M, González-Castro AM, Alonso-Cotoner C, Pigrau M, de Torres I, Rodiño-Janeiro BK, Salvo-Romero E, Fortea M, Pardo-Camacho C, Guagnozzi D, Azpiroz F, Santos J, Vicario M. Downregulation of mucosal mast cell activation and immune response in diarrhoea-irritable bowel syndrome by oral disodium cromoglycate: A pilot study. United European Gastroenterol J. 2017 Oct;5(6):887-897. doi: 10.1177/2050640617691690. Epub 2017 Jan 29. PMID: 29026603; PMCID: PMC5625876.

28 Wang J, Wang Y, Zhou H, Gu W, Wang X, Yang J. Clinical efficacy and safety of ketotifen in treating irritable bowel syndrome with diarrhea. Eur J Gastroenterol Hepatol. 2020 Jun;32(6):706-712. doi: 10.1097/MEG.0000000000001737. PMID: 32317585.

29 Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. doi: 10.1586/egh.09.72. PMID: 20136586.

30 Lembo AJ, Olden KW, Ameen VZ, Gordon SL, Heath AT, Carter EG. Effect of alosetron on bowel urgency and global symptoms in women with severe, diarrhea-predominant irritable bowel syndrome: analysis of two controlled trials. Clin Gastroenterol Hepatol. 2004 Aug;2(8):675-82. doi: 10.1016/s1542-3565(04)00284-8. PMID: 15290660.

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34 Pimentel M, Lembo A, Chey WD, Zakko S, Ringel Y, Yu J, Mareya SM, Shaw AL, Bortey E, Forbes WP; TARGET Study Group. Rifaximin therapy for patients with irritable bowel syndrome without constipation. N Engl J Med. 2011 Jan 6;364(1):22-32. doi: 10.1056/NEJMoa1004409. PMID: 21208106.

35 Chey WD, Shah ED, DuPont HL. Mechanism of action and therapeutic benefit of rifaximin in patients with irritable bowel syndrome: a narrative review. Therap Adv Gastroenterol. 2020 Jan 23;13:1756284819897531. doi: 10.1177/1756284819897531. PMID: 32047534; PMCID: PMC6984424.

36 Cash BD, Pimentel M, Rao SSC, Weinstock L, Chang L, Heimanson Z, Lembo A. Repeat treatment with rifaximin improves irritable bowel syndrome-related quality of life: a secondary analysis of a randomized, double-blind, placebo-controlled trial. Therap Adv Gastroenterol. 2017 Sep;10(9):689-699. doi: 10.1177/1756283X17726087. Epub 2017 Sep 11. PMID: 28932270; PMCID: PMC5598815.

37 Lembo A, Pimentel M, Rao SS, Schoenfeld P, Cash B, Weinstock LB, Paterson C, Bortey E, Forbes WP. Repeat Treatment With Rifaximin Is Safe and Effective in Patients With Diarrhea-Predominant Irritable Bowel Syndrome. Gastroenterology. 2016 Dec;151(6):1113-1121. doi: 10.1053/j.gastro.2016.08.003. Epub 2016 Aug 13. PMID: 27528177.

38 Munjal A, Dedania B, Cash B. Update on Pharmacotherapy for Irritable Bowel Syndrome. Curr Gastroenterol Rep. 2019 Apr 25;21(6):25. doi: 10.1007/s11894-019-0692-7. PMID: 31025114.

39 Black CJ, Burr NE, Camilleri M, Earnest DL, Quigley EM, Moayyedi P, Houghton LA, Ford AC. Efficacy of pharmacological therapies in patients with IBS with diarrhoea or mixed stool pattern: systematic review and network meta-analysis. Gut. 2020 Jan;69(1):74-82. doi: 10.1136/gutjnl-2018-318160. Epub 2019 Apr 17. PMID: 30996042.

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43 Chey WD, Lembo AJ, Lavins BJ, Shiff SJ, Kurtz CB, Currie MG, MacDougall JE, Jia XD, Shao JZ, Fitch DA, Baird MJ, Schneier HA, Johnston JM. Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety. Am J Gastroenterol. 2012 Nov;107(11):1702-12. doi: 10.1038/ajg.2012.254. PMID: 22986437.

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46 Chey WD, Lembo AJ, Rosenbaum DP. Efficacy of Tenapanor in Treating Patients With Irritable Bowel Syndrome With Constipation: A 12-Week, Placebo-Controlled Phase 3 Trial (T3MPO-1). Am J Gastroenterol. 2020 Feb;115(2):281-293. doi: 10.14309/ajg.0000000000000516. PMID: 31934897; PMCID: PMC7771640.

47 Stripling J, Rodriguez M. Current Evidence in Delivery and Therapeutic Uses of Fecal Microbiota Transplantation in Human Diseases-Clostridium difficile Disease and Beyond. Am J Med Sci. 2018 Nov;356(5):424-432. doi: 10.1016/j.amjms.2018.08.010. Epub 2018 Sep 5. PMID: 30384951.

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54 El-Salhy M, Hatlebakk JG, Gilja OH, Bråthen Kristoffersen A, Hausken T. Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study. Gut. 2020 May;69(5):859-867. doi: 10.1136/gutjnl-2019-319630. Epub 2019 Dec 18. PMID: 31852769; PMCID: PMC7229896.

 

Kapitel 10: Was Sie erwarten können und sollten

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5 Kumbhare SV, Francis-Lyon PA, Kachru D, Uday T, Irudayanathan C, Muthukumar KM, Ricchetti RR, Singh-Rambiritch S, Ugalde J, Dulai PS, Almonacid DE, Sinha R. Digital Therapeutics Care Utilizing Genetic and Gut Microbiome Signals for the Management of Functional Gastrointestinal Disorders: Results From a Preliminary Retrospective Study. Front Microbiol. 2022 Mar 21;13:826916. doi: 10.3389/fmicb.2022.826916. PMID: 35391720; PMCID: PMC8983270.